IPF1, IUF1, IDX-1, MODY4, PDX1, STF-1, Insulin promoter factor 1, Pancreas Duodenum Homeobox-1.
PDX1 activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. IPF1 is particularly involved in glucose-dependent regulation of insulin gene transcription. Pancreas Duodenum Homeobox-1 binds preferentially the DNA motif 5'-[ct]taat[tg]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At ***** stage, it is required for maintaining the hormone-producing phenotype of the beta-cell.
Recombinant PDX1 E.Coli derived.
Human and Mouse PDX-1.
35-40 kDa.
Stable for 2 yeas at -20°C. Avoid freeze/thaw cycles.
Western Blot: 1:1,000
Immunohistochemistry: 1:500
Optimal working dilutions must be determined by end user.
Routinely evaluated by western blot on lysates of rat pancreatic cell line INS-1
Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
